publicações selecionadas
-
artigo académico
- Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3. Mechanisms of Ageing and Development. 2025
- Rescue of respiratory and cognitive impairments in Rett Syndrome mice using NLX-101, a selective 5-HT1A receptor biased agonist. Biomedicine & Pharmacotherapy. 2025
- Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB-Dependent Mechanisms. International Journal of Molecular Sciences. 2025
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3. Journal of Clinical Investigation. 2024
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3 (IF: 19.47). The Journal of Clinical Investigation. 2024
- Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model. Biomedicine. 2023
- Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems. Biomedicine. 2023
- Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model. Biomedicine. 2023
- Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicine. 2022
- Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of Disease. 2021
- Mesenchymal stem cell secretome protects against alpha-synuclein-induced neurodegeneration in a Caenorhabditis elegans model of Parkinson's disease. Cytotherapy. 2021
- Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. Molecular Neurobiology. 2020
- The ARP2/3 complex prevents excessive formin activity during cytokinesis. Molecular Biology of the Cell. 2019
- Calcium Detection and Other Cellular Studies in the Esophagus and Crop of the Marine Slug Aglaja tricolorata (Euopisthobranchia, Cephalaspidea). Malacologia. 2014
- The effect of folate status on the uptake of physiologically relevant compounds by Caco-2 cells. European Journal of Pharmacology. 2010
-
artigo de conferência
-
documento
- Therapeutic efficacy of chronic 5-HT1A receptor agonism by NLX-112 (befiradol) in Spinocerebellar Ataxia Type 3 mice 2025
- Role of the serotonin receptor 5-HT3/LGC-50 in the suppression of Spinocerebellar Ataxia type 3 (SCA3) pathogenesis 2024
- Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of spinocerebellar ataxias 2024
- Therapeutic efficacy of chronic 5-HT1A receptor agonism by NLX-112 (befiradol) in Spinocerebellar Ataxia Type 3 mice 2024
- Serotonin transporter as a modifier of proteostasis in SCA3: insights from C. elegans 2024
- Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of Neurodegenerative Diseases 2024
- Therapeutic efficacy of chronic 5-HT1A receptor agonism by NLX-112 (befiradol) in Spinocerebellar Ataxia Type 3 mice" 2024
- ATXN3-mediated deubiquitylation of splicing factors regulates neuronal mRNA splicing and tau isoform ratio ATXN3 regulates SRSF7 levels and Tau ratio 2023
- The glucocorticoid receptor as a biomarker and neuronal therapeutic target of a disease-improving bile acid in SCA3/MJD 2023
- Pre and post-symptomatic treatment with NLX-112 improved the balance and motor coordination of the CMVMJD135 mouse model of Machado-Joseph Disease 2022
- Befiradol treatment ameliorated the motor dysfunction of Spinocerebellar Ataxia Type 3 mouse model 2022
- Multi-modal analyses converge on the 5-HT1A serotonin receptor and CREB signaling as promising therapeutic targets for SCA3 2022
- Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease 2022
- The molecular tweezer CLR01 reduces motor impairments and neuropathology in spinocerebellar ataxia type 3 in vivo models 2022
- Aripiprazole offsets mutant ATXN3-induced motor dysfunction by targeting dopamine D2 and serotonin 1A and 2A receptors in C. elegans. 2021
- Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans 2021
- Suppression of proteotoxic stress by serotonergic signaling 2021
- Suppression of proteotoxicity by serotonin signaling 2021
- Befiradol, a novel 5-HT1A receptor agonist, suppresses ATXN3 proteotoxicity in a C. elegans model of Machado-Joseph disease 2020
- The molecular tweezer CLR01 delay disease onset and reduce neurotoxicity in animal models of Machado-Joseph disease 2020
- Targeting of the serotonin (1A) receptor suppresses mutant ataxin-3 pathogenesis in C. elegans. 2019
- Serotonergic signaling activation suppresses proteotoxicity 2019
- NLX-112, a novel 5-HT1A receptor agonist, suppresses pathogenesis of mutant ATXN3 in C. elegans 2019
- Anti-aging genetic manipulation in C. elegans impact differentially in Machado-Joseph disease 2019
- A neuroprotective role played by secretome from mesenchymal stem cells against the action of a-synuclein on a Caenorhabditis elegans model of Parkinson’s Disease 2019
- Anti-aging genetic manipulation in C. elegans impact diferentially in Machado-Joseph disease 2019
- Genetic modifiers in Machado-Joseph disease 2019
- NLX-112, a full and potent 5-HT1A agonist, as a potential pharmacological treatment for Machado-Joseph Disease - Lessons from the worm 2019
- NLX-112, a novel 5-HT1A receptor agonist, supresses neuronal dysfunction in a C. elegans model of Spinocerebellar Ataxia 2019
- Serotonergic signaling modulation of protein homeostasis in C. elegans expressing firefly luciferase 2019
- Targeting of the Serotonin (1A) Receptor Suppresses Mutant Ataxin-3 Pathogenesis in C. elegans 2019
- Therapeutic Impact of the Modulation of Serotonergic Signaling in Caenorhabditis elegans Models of Proteotoxicity 2019
- Using luciferase mutants to study the impact of serotonergic signaling modulation of proteostasis in Caenorhabditis elegans 2019
- A novel 5-HT1A agonist supresses mutant ATXN3-mediated neuronal dysfunction in C. elegans 2018
- A novel 5-HT1A receptor agonist supresses mutant atxn3-mediated neuronal dysfunction in C. elegans 2018
- The effect of secretome from mesenchymal stem cells on two Caenorhabditis elegans models of Parkinson's disease 2018
- The secretome of mesenchymal stem cells exerts a protective effect towards a Caenorhabditis Elegans model of Parkinson’s Disease 2018
- Modulation of neuronal proteostasis by serotonin: impact on neurodegeneration 2017
- Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies
- Efficacy of chronic 5-HT 1A receptor agonism by NLX-112 in a mouse model of Spinocerebellar Ataxia type 3
- Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB Dependent Mechanisms
-
teses