publicações selecionadas
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artigo académico
- The chick chorioallantoic membrane assay as an in vivo model for colon tumor analysis with optical coherence tomography. Expert Systems with Applications. 2024
- Raman spectroscopy for classification of neoplastic and non-neoplastic CAM colon tumors. Heliyon. 2024
- The Chromenopyridine Scaffold: A Privileged Platform in Drug Design. Biomolecules. 2024
- In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer. RSC Medicinal Chemistry. 2024
- Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells. Biomaterials Advances. 2023
- Sustainable fluorescent dye-faujasite zeolite systems as tools for cancer bioimaging 2023
- Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review. International Journal of Molecular Sciences. 2023
- Targeted Treatment of Triple-Negative-Breast Cancer Through pH-Triggered Tumour Associated Macrophages Using Smart Theranostic Nanoformulations. International Journal of Applied Pharmaceutics. 2023
- Selective cytotoxicity of Portuguese propolis ethyl acetate and butanol fractions towards renal cancer cells. Biomolecules. 2022
- Imidazolylpyrrolone-Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma. Chemistry - A European Journal. 2022
- Renal cell carcinoma therapy: Current and new drug candidates. Drug Discovery Today. 2022
- In vivo efficacy studies of chromene-based compounds in triple-negative breast cancer: A systematic review. European Journal of Pharmacology. 2020
- Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy. Frontiers in Oncology. 2020
- Novel synthetic molecules bioinspired in natural phenolic compounds for anticancer drug discovery. Planta Medica. 2014
- Synthesis of 3-aminochromenes: The Zincke reaction revisited. Tetrahedron. 2014
- Anticancer activity of novel pyrido[2,3-b] indolizine derivatives: The relevance of phenolic substituents. Anticancer Research. 2014
- Tandem Cyclization of a Bispyridinium Chloride: Facile Synthesis of Substituted Indolizines. Synlett. 2013
- New chromene scaffolds for adenosine A2A receptors: Synthesis, pharmacology and structure-activity relationships. European Journal of Medicinal Chemistry. 2012
- Selective synthesis of some imidazopyridine-fused chromones. Tetrahedron. 2011
- 2-Aryl-1,9-dihydrochromeno[3,2-d]imidazoles: A facile synthesis from salicylaldehydes and arylideneaminoacetonitrile. Tetrahedron. 2011
- A one-pot synthesis of substituted pyrido[2,3-b]indolizines. Tetrahedron. 2011
- Synthesis of novel chromene scaffolds for adenosine receptors. Organic and Biomolecular Chemistry. 2011
- One-pot approach to the synthesis of novel 12H-chromeno[2',3':4,5]imidazo[1,2-a]pyridines in aqueous media. Tetrahedron. 2010
- Synthesis and Thermal Behavior of An Amorphous Solid Polymer Electrolyte. ECS Transactions. 2010
- A simple and eco-friendly approach for the synthesis of 2-imino and 2-oxo-2H-chromene-3-carboxamides. Green Chemistry. 2008
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artigo de conferência
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artigo de revista
- Glucose Metabolism Reprogramming in Bladder Cancer: Hexokinase 2 (HK2) as Prognostic Biomarker and Target for Bladder Cancer Therapy. Cancers. 2023
- Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells. Biomolecules. 2022
- Surface functionalization of zeolite-based drug delivery systems enhances their antitumoral activity in vivo. Journal of Nanoparticle Research. 2021
- Unravelling the anticancer potential of functionalized chromeno[2,3-b]pyridines for breast cancer treatment. Bioorganic Chemistry. 2020
- A Convenient One-pot Synthesis of Chromenyl Acrylates and Acrylonitriles. Synlett. 2020
- Exploitation of New Chalcones and 4H-chromenes as Agents for Cancer Treatment. European Journal of Medicinal Chemistry. 2018
- Adenine Derivatives: Promising Candidates for Breast Cancer Treatment. European Journal of Organic Chemistry. 2018
- Biological importance of structurally diversified chromenes. European Journal of Medicinal Chemistry. 2016
- Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. European Journal of Pharmaceutical Sciences. 2015
- Synthesis and electrochemical characterization of aPEO-based polymer electrolytes. Journal of Solid State Electrochemistry. 2012
- The Condensation of Salicylaldehydes and Malononitrile Revisited: Synthesis of New Dimeric Chromene Derivatives. Journal of Organic Chemistry. 2008
- Antifungal activity of a novel chromene dimer. Journal of Industrial Microbiology & Biotechnology. 2007
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capítulo de livro
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documento
- KDM4C epigenetic therapy for triple-negative breast cancer 2024
- Acoustic stimulation based on piezoelectric materials for reducing the proliferation of triple negative breast cancer cells 2024
- Design of new epigenetic inhibitors for the treatment of triple negative breast cancer 2024
- Therapeutic epigenetic KDM4C remodeling for the treatment of triple negative breast cancer 2024
- Synthesis of imidazo-pyridines/diazepines and evaluation of their anticancer potential in renal cell carcinoma cell lines 2023
- Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Animal Organism Phenotypic Assay 2023
- Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Organism Phenotypic Assay. 2023
- Virtual screening of potential KDM4C inhibitors for the treatment of triple negative breast cancer 2023
- New imidazole based scaffolds for the treatment of renal cell carcinoma 2023
- Biological characterization of novel chromeno[2,3-d]pyrimidinones as therapeutic approach for the treatment of triple-negative Breast Cancer 2023
- Chromene-based molecules: privileged scaffold for oncology drug development 2023
- Development of virtual screening protocols for the design of novel KDM4C inhibitors for the treatment of triple negative breast cancer 2023
- Synthesis of chromene[2,3-b]pyridines and characterization of their anticancer potential for the treatment of breast cancer 2023
- In vitro and in vivo evaluation of novel chromeno[2,3-d]pyrimidinones as therapeutic agents for triple negative breast cancer 2023
- New imidazole derivatives as anticancer agents for the treatment of renal cell carcinoma 2023
- Optimization of specialized virtual screening protocols for the design of new KDM4C inhibitor molecules for the treatment of triple negative breast cancer 2023
- Otimização de protocolos especializados de virtual screening para o design de novas moléculas inibidoras da KDM4C para o tratamento do cancro da mama triplo negativo 2023
- Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay 2023
- Treatment of triple-negative breast cancer through externally triggered target-less drug carriers 2023
- Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review 2023
- Studies on the acylation reaction of salicylaldehyde 2022
- Chromen[2,3-b]pyridines: synthesis and evaluation of the anticancer potential for breast cancer treatment 2022
- Studies on the synthesis of new heterocycles based on the chromene and purine nucleus 2022
- In vitro validation of a new magnetic solid lipid nanoformulation against Triple-Negative Breast Cancer 2021
- Validation of a new nanoformulation for the diagnostic and treatment of triple-negative breast cancer 2021
- Validação de uma nova nanoformulação direcionada para o diagnóstico e tratamento do cancro da mama triplo-negativo 2021
- A new lead compound for triple negative breast cancer therapy 2021
- New chromene derivatives: overcoming renal cell carcinoma drug resistance 2021
- A new therapeutic option for triple negative breast cancer 2021
- Hexokinase II (HKII) is a prognostic biomarker for bladder cancer patients: Antitumoral activity of the HKII inhibitor 2-deoxy-D-glucose 2021
- Novel therapy for renal cell carcinoma: overcoming drug resistance 2021
- Engineered exosome-mediated delivery of RNAi therapeutics towards triple negative breast cancer therapy 2021
- In vitro validation of new theranostic nanoformulation against Triple-negative breast cancer 2021
- Upregulation of Hexokinase II (HKII) impacts survival of bladder cancer patients: Effects of HKII inhibition by 2-deoxy-D-glucose 2021
- In vitro validation of a new magnetic formulation against Trile-negative breast cancer 2021
- Anti-cancer activity of Portuguese propolis fractions and isolated compounds 2021
- In vitro validation of a new magnetic formulation against Triple-Negative Breast Cancer 2021
- In vitro validation of a new theranostic nanoformulation against Triple-Negative Breast Cancer 2021
- Characterization of the biological activity of functionalized chromeno[2,3-b]pyridines for breast cancer treatment 2020
- New substituted 3,5-dihydro-4H-chromeno [2,3-d] pyrimidin-4-one: a promising strategy for breast cancer treatment 2020
- Unravelling the anticancer potential of novel compounds for breast cancer therapy 2020
- New chromene derivatives: unravelling the molecular mechanisms for breast cancer treatment 2019
- Chromene derivatives: a new strategy to overcome renal cancer resistance 2019
- Exploitation of novel chromene derivatives for breast cancer treatment 2019
- Synthesis and biological activity of new anticancer agents for breast cancer treatment 2019
- New molecules based on chromene moiety as candidates for renal cell carcinoma therapy 2019
- New chromene derivatives: Unraveling the molecular mechanisms for breast cancer therapy 2019
- Chromene-based compounds as candidates for renal cell cancer treatment 2019
- In vitro and in vivo efficacy evaluation of drug delivery systems based on zeolites 2019
- Synthesis of functionalized chromeno[2,3-b]pyridines: promising agents for breast cancer treatment 2019
- Biological activity of novel targeted inhibitors for renal cell cancer therapy 2019
- In vitro and in vivo evaluation of new chromene derivatives as potent anticancer agents 2019
- Chromene-based molecules as targeted inhibitors for renal cell cancer therapy 2019
- New chromene-based molecules as microtubule destabilizers and pro-apoptotic agents in cancer 2018
- Chemical and biological characterization of chalcones and 4H-chromenes: exploitation as anticancer agents 2018
- Unraveling the anticancer molecular mechanisms of new chromene-based drugs 2018
- Discovery of chromene-based molecules as apoptosis-inducers by G2/M cell-arrest 2018
- Chromene-based drug candidates for cancer treatment 2018
- New chromene-based drug candidates for cancer treatment 2017
- Chromene derivatives as anticancer agents: synthesis and biological evaluation 2016
- Chromene-based new drug candidates for cancer treatment 2016
- Anticancer profile of a selection of new chromene-based compounds 2015
- Reactivity of 3-pyridinium coumarins with carbon nucleophiles 2015
- Novel synthetic molecules bioinspired in natural phenolic compounds for anticancer drug discovery 2014
- Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells 2014
- 3-aminocoumarins: synthesis and reaction with active carbonyl compounds 2013
- Pyrido[2,3-b]indolizines: a one-pot synthesis in green media 2013
- Some reactions of active methylene compounds with 2-hydroxychalcones 2013
- Synthesis of new chromene derivatives and pharmacological evaluation for adenosine receptors 2013
- Synthesis and anticancer activity of novel chromeno-imidazo[1,2-a]pyridines 2012
- Synthesis and pharmacological evaluation of new chromene scaffolds for adenosine receptors 2012
- Synthesis of 1-(2-imino-2H-chromen-3-yl)pyridinium chloride derivatives as potential anticancer agents 2012
- Synthesis of new chromene derivatives as potencial anticancer agents 2012
- N-Methyl piperazine: an important fragment for interaction with serotonine 5-HT2a receptors 2010
- New scaffold for adenosine receptors 2010
- Characterisation and catalytic activity of copper(II) complexes with chromene derivatives 2009
- Synthesis of 12H-chromeno[2´,3´:4,5]imidazo[1,2-a]pyridine by a base catalysed cascade cyclisation approach 2009
- Synthesis of aryl piperazine derivatives as potential antipsychotics 2009
- A simple and eco-friendly approach for the synthesis of 2-imino-2H-chromene-3-carboxamides 2008
- Synthesis of 2-imino-2H-chromene-3-carboxamides with affinity for serotonin receptors 2008
- Synthesis and in vitro antifungal activity of a novel chromene derivative 2007
- Some Reactions of (2-amino-3-cyano-4H-chromen-4-yl)malononiytile 2006
- The Condensation of Aromatic Aldehydes and Malononitrile Revisited 2006
- The Reaction of 2-Oxo-2H-chromene-3-carbonitrile with 2-Methoxyethylamine 2006