publicações selecionadas
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artigo académico
- Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase. J Med Chem. 2002
- BIA 3-202, a long-acting catechol-O-methyltransferase inhibitor with limited brain access. British Journal of Pharmacology. 2000
- Kinetics of rat brain and liver solubilized membrane-bound catechol-O-methyltransferase. Arch Biochem Biophys. 2000
- Effect of brain catechol-O-methyltransferase inhibition by tolcapone on amphetamine-induced behaviour in the rat. British Journal of Pharmacology. 1999
- Rat liver catechol-O-methyltransferase kinetics and assay methodology. J Enzyme Inhib. 1998
- Sensitivity to inhibition by tolcapone of soluble and membrane-bound forms of catechol-O-methyltransferase from rat brain, liver and kidney. British Journal of Pharmacology. 1997
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documento