publicações selecionadas
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artigo académico
- Chiral hydroxymethyl-1H,3H-pyrrolo[1,2-c] thiazoles: the search for selective p53-activating agents for colorectal cancer therapy. RSC Medicinal Chemistry. 2024
- Cytotoxicity of Frutalin on Distinct Cancer Cells Is Independent of Its Glycosylation. Biomolecules. 2021
- A selective p53 activator and anticancer agent to improve colorectal cancer therapy. Cell Reports. 2021
- Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives against Candida albicans and Candida krusei. African Journal of Biotechnology. 2021
- SLMP53-1 interacts with wild-type and mutant p53 DNA-binding domain and reactivates multiple hotspot mutations. Biochimica et Biophysica Acta (BBA). General Subjects. 2020
- SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers. 2019
- The crystal structure of the R280K mutant of human p53 explains the loss of DNA binding. International Journal of Molecular Sciences. 2018
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documento
- Redefining ovarian cancer treatment with a first-in-class inhibitor of homologous recombination DNA repair. Annals of Oncology. 2025
- A first-in-class inhibitor of homologous recombination DNA repair counteracts tumour growth, metastasis and therapeutic resistance in pancreatic cancer. Journal of Experimental & Clinical Cancer Research. 2025
- Targeting p53 for melanoma treatment: counteracting tumour proliferation, dissemination and therapeutic resistance 2021
- Semi-synthesis of small molecules of aminocarbazoles: tumor growth inhibition and potential impact on p53 2021
- The loss of DNA binding function of a Human p53 mutant elucidated through X-ray crystallography 2019
- Crystal structure of Human p53 R280K mutant (DNA binding domain) ¿ Explaining the loss of DNA binding 2018
- Uncovering the binding of the anticancer small molecule SLMP53-1 to mutant p53R280K 2017
- Distinct regulation of p53-mediated apoptosis by protein kinase calpha, delta, epsilon and zeta: evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms. Experimental Cell Research. 2011
- Modulation of Bax by Protein Kinase C in yeast 2011
- Modulation of bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase calpha. Experimental Cell Research. 2011
- The importance of humanized yeast to better understand the role of Bcl-2 family in apoptosis : finding of novel therapeutic opportunities. Current Pharmaceutical Design. 2011