resumo Supplementary data to this article can be found online at https://doi. org/10.1016/j.biteb.2022.100992.
palavras-chave Ashbya gossypii De novo pyrimidine biosynthesis Dihydroorotate dehydrogenase Orotic acid Orotic acid (PubChem CID: 967) Saccharomyces cerevisiae URA9