publicações selecionadas
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artigo académico
- Darifenacin: a promising chitinase 3-like 1 inhibitor to tackle drug resistance in pancreatic ductal adenocarcinoma. Cancer Chemotherapy and Pharmacology. 2024
- Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates and Antitumor Activity Evaluation: Studies In Vitro and In Ovo Grafts of Chick Chorioallantoic Membrane (CAM) with a Triple Negative Breast Cancer Cell Line. Biomolecules. 2021
- Synthesis of novel 8-(het)aryl-6H-pyrano[4',3':4,5]thieno[3,2-b]pyridines by 6-endo-dig cyclization of Sonogashira products and halolactonizations with Cu salts/NXS. Preliminary antitumor evaluation. Tetrahedron. 2019
- Chemical features of Ganoderma polysaccharides with antioxidant, antitumor and antimicrobial activities. Phytochemistry. 2015
- New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death. European Journal of Medicinal Chemistry. 2013
- Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells. Biomolecules. 2012
- Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies. European Journal of Medicinal Chemistry. 2011
- Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure–activity relationships, effects on the cell cycle and apoptosis. European Journal of Medicinal Chemistry. 2011
- Synthesis of aminodiarylamines in the thieno[3,2-b]piridine series and effects on tumour cell growth inhibition, cell cycle and apoptosis. Revista Portuguesa de Farmácia. 2011
- Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle. European Journal of Medicinal Chemistry. 2010
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documento
- Chitinase 3-like-1 identified in large extracellular vesicles from human macrophages: a promising therapeutic drug target for pancreatic cancer (Best Poster Award in the session I of EVs in Cancer) 2023
- Targeting Chitinase-like-1 (CHI3L1) as a therapeutic target for pancreatic cancer 2021
- Targeting chitinase 3-like 1 in pancreatic cancer: in silico identification of inhibitors from a DrugBank database and confirmation of growth inhibition effect in cell lines 2021
- Gonoderma luicidium methanolic extract: chemical characterization in phenolic compounds and study of growth inhibitory activity in human tumor cell lines 2013
- Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line. Food Research International. 2013