publicações selecionadas
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artigo académico
- Manifestations of Anxiety, Cognition and Mood functions in the CMVMJD135 Mouse Model of MJD/SCA3. Elife. 2026
- The loss of Tau in the adult brain triggers neuroplastic, epigenetic and behavioral deficits. International Journal of Medical Microbiology. 2026
- Rescue of respiratory and cognitive impairments in Rett Syndrome mice using NLX-101, a selective 5-HT1A receptor biased agonist. Biomedicine & Pharmacotherapy. 2025
- Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies. International Journal of Medical Microbiology. 2025
- Loss of function of Tau in the adult brain leads to synaptic dysfunction through nucleosome destabilization. Nature Comm. 2025
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3. Journal of Clinical Investigation. 2024
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3 (IF: 19.47). The Journal of Clinical Investigation. 2024
- Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP3R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3. International Journal of Molecular Sciences. 2023
- Reduction of Tau in the adult brain dysregulates epigenetic homeostasis and neuroplasticity. Nature Genetics. 2023
- Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3. Disease Models & Mechanisms. 2022
- Profiling Microglia in a Mouse Model of Machado-Joseph Disease. Biomedicine. 2022
- Integration of behavior and neuronal physiology in a mouse model of Rett Syndrome: a focus on serotonergic system modulation. Journal of Neurochemistry. 2022
- Microglial Depletion Has No Impact on Disease Progression in a Mouse Model of Machado-Joseph Disease. Cells. 2022
- Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response. International Journal of Molecular Sciences. 2021
- Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain. Neuroscience. 2021
- Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in Stress and Aß-evoked hippocampal pathology. Elife. 2020
- Prognostic significance of monocarboxylate transporter expression in oral cavity tumors. Cell Cycle. 2016
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artigo de conferência
- Assessing the HPA-axis mediated stress responses in a mouse model of SCA3 2023
- The molecular tweezer CLR01 reduces motor impairments and neuropathology in spinocerebellar ataxia type 3 in vivo models 2022
- The study of depression and cognitive comorbidities in a mouse model of spinocerebellar ataxia type 3 2022
- Universidade sénior: ciência em educação não-formal 2018
- A utopia do consentimento informado 2017
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documento
- Defining novel behavioral traits, brain proteomic signatures and new therapeutic opportunities in a clinically relevant mouse model of Rett Syndrome 2025
- From central to peripheral perspectives in Machado-Joseph Disease: disentangling new therapeutic avenues 2025
- ATXN3 is A Key Regulator of Neuronal Splicing and Tau Isoform Dynamics 2024
- Noradrenergic Degeneration in a DJ-1 Knockout mouse model 2024
- Characterization of the movement disorder phenotype of a mouse model of Down Syndrome 2024
- Selective biased agonism of 5-HT1AR rescues respiratory and cognitive impairments but not the movement disorder component in Rett Syndrome mice 2024
- Therapeutic efficacy of chronic 5-HT1A receptor agonism by NLX-112 (befiradol) in Spinocerebellar Ataxia Type 3 mice 2024
- Understanding the regulation of stress responses in a mouse model of SCA3 2024
- ATXN3-mediated deubiquitylation of splicing factors regulates neuronal mRNA splicing and tau isoform ratio ATXN3 regulates SRSF7 levels and Tau ratio 2023
- Assessing the HPA-axis mediated stress responses in a mouse model of SCA3 2023
- Limited Therapeutic Impact of Intermittent Fasting and Ketogenic diets in a Mouse Model of Spinocerebellar Ataxia Type 3 2023
- The glucocorticoid receptor as a biomarker and neuronal therapeutic target of a disease-improving bile acid in SCA3/MJD 2023
- Noradrenergic Degeneration in a DJ-1 Knockout mouse model 2023
- Defining novel behavioural and neurophysiological features and testing a 5HT1A-targeting therapeutic agent in a clinically relevant mouse model of Rett Syndrome 2022
- The study of depression and cognitive comorbidities in a mouse model of spinocerebellar ataxia type 3 2022
- Stress resilience in SCA3: study of depression and cognitive comorbidities in a mouse model 2022
- Glucocorticoid receptor as a biomarker and neuronal therapeutic target of a disease-improving bile acid in SCA3/MJD 2022
- The molecular tweezer CLR01 reduces motor impairments and neuropathology in spinocerebellar ataxia type 3 in vivo models 2022
- The study of depression and cognitive comorbidities in a mouse model of spinocerebellar ataxia type 3" 2022
- Understanding the relevance of the cerebellar cognitive affective syndrome in SCA3 mice 2022
- Can chronic activation of serotonergic signalling be a therapeutic approach for neurodegenerative diseases? 2021
- Can chronic activation of serotonergic signalling be atherapeutic approach for neurodegenerative diseases? 2021
- Do MJD mice present a cerebellar cognitive affective syndrome? 2021
- Integration of behavior and neuronal physiology in a mouse model of Rett Syndrome: a focus on serotonergic system modulation 2021
- Does activation of serotonergic treatment suppress proteotoxicity in mouse models of neurodegenerative diseases? 2021
- Does activation of serotonergic treatment suppressproteotoxicity in mouse models of neurodegenerative diseases? 2021
- Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Disorders 2021
- Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Diseases 2021
- Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Diseases 2020
- Impact of astrocytic calcium suppression in the pathogenesis of Machado-Joseph disease 2020
- A positive modulator of AMPA receptors against AD pathology: in vivo studies 2018
- A novel allosteric modulator of AMPA receptor against Alzheimer’s disease pathology 2018
- A novel modulator of AMPA receptors against AD pathology: the first in vivo evidence 2018
- Universidade sénior: ciência em educação não-formal 2018
- A novel modulator of AMPA receptors against AD pathology: the first in vivo evidence 2017
- Identifying the molecular underpinning of altered corticosteroid milieu in brain 2017
- Efficacy of chronic 5-HT 1A receptor agonism by NLX-112 in a mouse model of Spinocerebellar Ataxia type 3
- The 5-HT 1A receptor agonist NLX-112 rescues motor swimming deficits in Spinocerebellar Ataxia type 3 mice
- Understanding corticosterone fluctuations and HPA-axis regulation in a mouse model of Spinocerebellar ataxia type 3
- iPSC-derived MSC secretome activates distinct neuroprotective pathways in a preclinical model of Parkinson’s disease