Publicações no PortAberta

 

Co-autor de rede

Mapa da Ciência

Co-investigador da Rede

Nuno Miguel Sampaio Osório

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Publicações

publicações selecionadas

• artigo académico

  • Antibiotic resistance: Assessing knowledge and misconceptions among Portuguese students and science teachers.  Biochemistry and Molecular Biology Education.  2024
  • Dispersal history of SARS-CoV-2 in Galicia, Spain.  Journal of Medical Virology.  2024
  • Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis.  Respiratory Research.  2024
  • Breaking Boundaries in Malaria Research: Design of a Genetic Tool for High-Throughput Gametocidal Drug Screening.  Journal UMinho Science.  2024
  • A transcriptomic profiling reveals novel roles of Cadherin-3 in metabolic programming of glioblastoma 2024
  • Artemisinin resistance-associated gene mutations in Plasmodium falciparum: A case study of severe malaria from Mozambique.  Travel Medicine and Infectious Disease.  2023
  • Demystifying dimensionality reduction techniques in the ‘omics’ era: A practical approach for biological science students.  Biochemistry and Molecular Biology Education.  2023
  • Development of polyurethane antimicrobial coatings by composition with phenolic-, ionic- and copper-based agents.  Journal of Materials Research and Technology.  2023
  • The evolution of the HIV-1 protease folding stability.  Virus Evolution.  2022
  • The impact of single-cell genomics on the field of mycobacterial infection.  African Journal of Biotechnology.  2022
  • Reply to: Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass.  Nature Communications.  2022
  • PMMA Microcapsules for the Inactivation of SARS-CoV-2.  ACS Omega.  2022
  • Tuberculosis caused by Mycobacterium africanum: Knowns and unknowns..  PLoS Pathogens.  2022
  • Development of an Ultraviolet-C Irradiation Room in a Public Portuguese Hospital for Safe Re-Utilization of Personal Protective Respirators.  International Journal of Environmental Research and Public Health.  2022
  • The Neglected Contribution of Streptomycin to the Tuberculosis Drug Resistance Problem.  Genes.  2021
  • Evolutionary dynamics of HIV-1 subtype C in Brazil.  Acta Cytologica.  2021
  • OmniSARS2: A Highly Sensitive and Specific RT-qPCR-Based COVID-19 Diagnostic Method Designed to Withstand SARS-CoV-2 Lineage Evolution.  Biomedicine.  2021
  • Characterizing HIV-1 Genetic Subtypes and Drug Resistance Mutations among Children, Adolescents and Pregnant Women in Sierra Leone.  Genes.  2021
  • Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes.  Nature Communications.  2021
  • Heterogeneous Streptomycin Resistance Level Among Mycobacterium tuberculosis Strains From the Same Transmission Cluster.  African Journal of Biotechnology.  2021
  • Nationwide Study of Drug Resistance Mutations in HIV-1 Infected Individuals under Antiretroviral Therapy in Brazil.  International Journal of Molecular Sciences.  2021
  • Evolutionary Genetics of Mycobacterium Tuberculosis and HIV-1: "The Tortoise and the Hare".  African Journal of Biotechnology.  2021
  • Increased circulation time of Plasmodium falciparum underlies persistent asymptomatic infection in the dry season.  Nature Medicine.  2020
  • Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.  Nature Communications.  2020
  • Implication of SARS-CoV-2 evolution in the sensitivity of RT-qPCR diagnostic assays.  Lancet Infectious Diseases.  2020
  • Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production.  Nature Communications.  2020
  • Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.  PLoS Neglected Tropical Diseases.  2020
  • SNAPPy: A snakemake pipeline for scalable HIV-1 subtyping by phylogenetic pairing.  Virus Evolution.  2019
  • Characterization of a large cluster of HIV-1 A1 infections detected in Portugal and connected to several Western European countries.  Acta Cytologica.  2019
  • Predictors and outcomes of disseminated tuberculosis in an intermediate burden setting.  Chest.  2019
  • Machine Learning-Enhanced T Cell Neoepitope Discovery for Immunotherapy Design.  Cancer Informatics.  2019
  • The Troika Host–Pathogen–Extrinsic Factors in Tuberculosis: Modulating Inflammation and Clinical Outcomes.  Frontiers in Immunology.  2018
  • A Nonribosomal Peptide Synthase Gene Driving Virulence in Mycobacterium tuberculosis.  Msphere.  2018
  • Mycobacterium tuberculosisComplex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition.  Genome Biology and Evolution.  2017
  • A Prediction Rule to Stratify Mortality Risk of Patients with Pulmonary Tuberculosis 2016
  • Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of Non-B and Non-G Subtypes.  Journal of Clinical Microbiology.  2015
  • Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response.  Antimicrobial Agents and Chemotherapy.  2014
  • Drawings as snapshots of student cellular anatomy understanding.  Medical Education.  2013
  • Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response 2013
  • Evidence for Diversifying Selection in a Set of Mycobacterium tuberculosis Genes in Response to Antibiotic- and Nonantibiotic-Related Pressure.  Molecular Biology and Evolution.  2013
  • Morphological heterogeneity of Paracoccidioides brasiliensis: Relevance of the Rho-like GTPase PbCDC42.  Blood.  2012
  • The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma.  Genes and Immunity.  2012
  • The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation 2011
  • Neurodevelopmental delay in theCln3¿ex7/8mouse model for Batten disease.  Genes, Brain and Behavior.  2009
  • NO-mediated apoptosis in yeast.  Journal of Cell Science.  2007
  • Nitric Oxide Signaling Is Disrupted in the Yeast Model for Batten Disease.  Molecular Biology of the Cell.  2007

• artigo de conferência

  • Evidence for NO-mediated apoptosis in yeast 2007

• capítulo de livro

  • Investigação ao serviço da sociedade 2020
  • The role of nitric oxide signalling in yeast stress response and cell death. 2017
  • Batten disease: overview and current research topics 2010

• documento

  • Molecular and Phenotypic Characterization of Antimalarial Drugs Resistance in Plasmodium falciparum from Angola 2025
  • Enhancing Human Malaria Parasites for Large-Scale Multistage Drug Screening 2024
  • Red Fluorescent & Luminescent Malaria Parasites: A Novel Tool for High-Throughput Gametocidal Drug Screening 2024
  • Engenharia de Parasitas da Malária Humana para triagem de drogas em multiplas etapas de alto rendimento 2024
  • Anemia hemolítica autoimune VS Síndrome neurológica após tratamento com artesunato em pacientes com malária por Plasmodium falciparum, na Clínica Multiperfil entre Junho e Agosto de 2023 Luanda/Angola: relato de 6 casos. 2024
  • Enginnering a Transgenic Human Malaria Parasite Reporter Line for Multistage Drug Screening 2024
  • Breaking Boundaries in Malaria Research: Design of a Genetic Tool for High-Throughput Gametocidal Drug Screening 2024
  • Engineering Human Malaria Parasites for Highthroughput Gametocidal Drug Screening 2024
  • Enhancing malaria elimination strategies in the Dominican Republic: Evaluating rapid diagnostic test accuracy and unraveling parasite genetic diversity 2024
  • Assessing malaria rapid diagnostic test accuracy and genetic diversity in the Dominican Republic: Implications for elimination efforts 2023
  • Spatiotemporal profiling of gene expression during sarcoid granuloma formation 2023
  • A transcriptomic profiling reveals novel roles of Cadherin-3 in metabolic programming of glioblastoma 2023
  • Assessing textile antiviral properties 2022
  • The Plasmodium falciparum protein PfMRP1 functions as an influx ABC transporter 2022
  • Tuberculosis severity and its association with pathogen phylogeny and properties 2017
  • HIV and tuberculosis co-infection: A 7 year retrospective cohort study 2015
  • Mycobacterium tuberculosis strains are differentially recognized by TLRs with an impact on innate immune responses and the outcome of infection: P1313 2012
  • Uncovering pathological mechanisms underlying Batten disease : from yeast to more complex models systems 2009
  • Studying the role of nitric oxide in the pathological mechanism of Batten disease 2008
  • Evidence for NO-mediated apoptosis in yeast 2007
  • Evidence of NO-mediated apoptosis in yeast 2007
  • Uncovering Saccharomyces cerevisiae active cell death pathways: oxidative versus acid stress 2006
  • Biomedical Research During the COVID-19 Pandemic: Success in Sars-Cov-2 and Other Infectious Diseases
  • Genética: Descobrindo Novos Fármacos contra a Malária
  • Genética: Descobrindo Novos Fármacos contra a Malária
  • HABIT - a web server for interactive T cell neoepitope discovery
  • HanDBr: A relational database with data from 50k HIV-1 infections detected in Brazil from 2008 to 2017
  • SARS-CoV-2 genome sequences from samples isolated at ICVS. Dataset: high throughput sequencing metadata
  • SNAPPy: a snakemake pipeline for pathogen subtyping by phylogenetic pairing
  • SPINET: Syndemic Protein Interaction NETworks
  • Transcriptome datasets for Plasmodium falciparum 3D7 and Dd2: high throughput sequencing data
  • Transcriptome of human macrophages infected with Aspergillus fumigatus. Dataset: high throughput sequencing data
  • Transmission of streptomycin resistance in Mycobacterium tuberculosis infections. Dataset: high throughput sequencing data.

Pesquisas

investigador principal

• Decifrar a Adaptabilidade Patogénica: uma abordagem bioinformática aos agentes infeciosos humanos mais relevantes  concedido pelo Fundação para a Ciência e Tecnologia 2029
• Translating Mechanisms of Mycobacterium tuberculosis Evolution into Therapeutic Insights  concedido pelo Fundação para a Ciência e Tecnologia 2020
• YEAST MODELS OF NEURONAL CEROID LIPOFUSCINOSIS: FROM DIFFERENT GENES TO COMMON BIOLOGICAL FEATURES 2009

outras atividades de investigação

• Deep into the malaria parasite Hemozoin Pathway for Targeted Antimalarial Strategies
• Deregulation of hematopoiesis by Interleukin-10 over-expression: implications for the development of hematological disorders
• Host-microbiome interactions in the quest for Fibrosing ILD Biomarkers that Rule Acceleration (FIBRA-Lung)
• ICVS/3B's - Associate Laboratory
• ICVS/3B's - Associate Laboratory
• ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
• ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
• ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
• Malaria Therapeutic Failure Prediction using Machine Learning
• A interação hospedeiro-microbiota: novos biomarcadores e terapia na infeção fúngica invasiva
• ELUCIDAÇÃO DE MECANISMOS PATOLÓGICOS ASSOCIADOS A FORMA JUVENIL DA LIPOFUSCINOSE CERÓIDE NEURONAL: DO MODELO DE LEVEDURA PARA SISTEMAS MAIS COMPLEXOS
• Projecto Estratégico - LA 26 - 2011-2012
• Projecto Estratégico - LA 26 - 2013-2014
• Reforço da resposta à pandemia de COVID-19 através do desenvolvimento deferramentas de diagnóstico e aumento da capacidade.

Fundo

prémios e distinções

• IACOBUS PAPERS IV, conferido pelo Xunta de Galicia, 2022
• Best Paper Award, conferido pelo Portuguese Society for Immunology, 2021
• Support for Innovation and Development Projects for Teaching and Learning, conferido pelo Universidade do Minho, 2020
• Prémio Thomé Villar, conferido pelo Sociedade Portuguesa de Nefrologia, 2017
• Prémio Robalo Cordeiro, conferido pelo Sociedade Portuguesa de Nefrologia, 2015
• Best Poster - MicroBiotec`11, conferido pelo Sociedade Portuguesa de Biotecnologia, 2011
• Young Investigator Award - "Prémio Jovem Investigador, Isabel Spencer-Martins" 2010, conferido pelo Sociedade Portuguesa de Microbiologia, 2010
• Posdoc Grant, conferido pelo Fundação para a Ciência e Tecnologia, 2009
• Grant for a Technology Transfer Internship at University of Texas at Austin IC2 institute, conferido pelo Fundação para a Ciência e Tecnologia, 2009
• Business Plan Development Grant, conferido pelo Instituto do Emprego e Formacao Profissional, 2008
• Best Business Ideia of the Year, 2006
• PhD Grant, conferido pelo Fundação para a Ciência e Tecnologia, 2005
• Prize of Academic Merit, conferido pelo Universidade do Minho, 2003
• Erasmus Grant, conferido pelo European Union, 2003