publicações selecionadas
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artigo académico
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3 (IF: 19.47). The Journal of Clinical Investigation. 2024
- Development of a Versatile Toolbox for Genetic Manipulation of Sporothrix brasiliensis. Microbiology Spectrum. 2023
- Glutamine Metabolism Supports the Functional Activity of Immune Cells against Aspergillus fumigatus. Microbiology Spectrum. 2023
- Untangling the biological and inflammatory behavior of silk-like sutures In vivo. Biomaterials. 2022
- IL-10 Overexpression After BCG Vaccination Does Not Impair Control of Mycobacterium tuberculosis Infection.. Frontiers in Immunology. 2022
- Dysregulation of glycerophospholipid metabolism during Behçet's disease contributes to a pro-inflammatory phenotype of circulating monocytes. Emerging Microbes & Infections. 2021
- Innovative, integrative, and interactive in-class activity on metabolic regulation: Evaluating educational impacts. Biochemistry and Molecular Biology Education. 2021
- Early IL-10 promotes vasculature associated CD4+ T cells unable to control Mycobacterium tuberculosis infection. JCI Insight. 2021
- Aspergillus fumigatus Acetate Utilization Impacts Virulence Traits and Pathogenicity. Mbio. 2021
- Paracoccin Overexpression in Paracoccidioides brasiliensis Enhances Fungal Virulence by Remodeling Chitin Properties of the Cell Wall. Journal of Infectious Diseases. 2021
- Correction: A Prediction Rule to Stratify Mortality Risk of Patients with Pulmonary Tuberculosis.. Antibiotics. 2020
- Characterization of a heme-protein responsive to hypoxia in Paracoccidioides brasiliensis. Fungal Genetics and Biology. 2020
- Molecular characterization of siderophore biosynthesis in Paracoccidioides brasiliensis.. Ima Fungus. 2020
- Pathogenic Allodiploid Hybrids of Aspergillus Fungi.. Current biology : CB. 2020
- Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity. Nature Communications. 2020
- Mycobacterium tuberculosis associated with severe tuberculosis evades cytosolic surveillance systems and modulates IL-1ß production. Nature Communications. 2020
- Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. Msphere. 2020
- The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Reports. 2020
- Synthetic and minimalist vectors for Agrobacterium tumefaciens-mediated transformation of fungi. Genetics and Molecular Biology. 2019
- Correction: The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells [The Journal of Experimental Medicine, 213, 10, (2016)] https://doi.org/10.1084/jem.20150282. Journal of Experimental Medicine. 2017
- IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity. Journal of Allergy and Clinical Immunology. 2017
- Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of Non-B and Non-G Subtypes. J. Clin. Microbiol.. 2015
- PTX3-Based Genetic Testing for Risk of Aspergillosis after Lung Transplant. Clinical Infectious Diseases. 2015
- Drawings as snapshots of student cellular anatomy understanding. Medical Education. 2013
- Erratum: The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans (Molecular Microbiology (2010) 75 (1372-1388)). Molecular Microbiology. 2010
- The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans (vol 75, pg 1372, 2010). Molecular Microbiology. 2010
- Mismatches between the conceptual level of tests and faculty beliefs. Faseb Journal. 2009
- Non-tuberculous mycobacteria: Patterns of isolation. A multi-country retrospective survey. International Journal of Tuberculosis and Lung Disease. 2004
- Construction of a genomic library of the food spoilage yeast Zygosaccharomyces bailii and isolation of the ß-isopropylmalate dehydrogenase gene (ZbLEU2). FEMS Yeast Research. 2001
- Isolation and sequence analysis of the gene encoding triose phosphate isomerase from Zygosaccharomyces bailii. Yeast. 2001
- Oxygen Requirements of the Food Spoilage Yeast Zygosaccharomyces bailii in Synthetic and Complex Media. Applied and Environmental Microbiology. 2001
- Red fluorescent protein (DsRed) as a reporter in Saccharomyces cerevisiae. Journal of Bacteriology. 2001
- Mechanisms underlying the transport and intracellular metabolism of acetic acid in the presence of glucose in the yeast Zygosaccharomyces bailii. Microbiology. 1998
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artigo de conferência
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artigo de revista
- Interacting with Hemoglobin: Paracoccidioides spp. Recruits hsp30 on Its Cell Surface for Enhanced Ability to Use This Iron Source. Journal of Fungi. 2021
- Antimicrobial coating of spider silk to prevent bacterial attachment on silk surgical sutures. Acta Biomaterialia. 2019
- Ploidy Determination in the Pathogenic Fungus Sporothrix spp.. Antibiotics. 2019
- Predictors and outcomes of disseminated tuberculosis in an intermediate burden setting. Chest. 2019
- The Aspergillus fumigatus mismatch repair MSH2 homolog is important for virulence and azole resistance. Msphere. 2019
- Silk-Based Antimicrobial Polymers as a New Platform to Design Drug-Free Materials to Impede Microbial Infections. Acta Biomaterialia. 2018
- The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis. Cytokine. 2018
- L-Threonine Supplementation During Colitis Onset Delays Disease Recovery. Frontiers in Physiology. 2018
- Cellular Metabolism at a Glance. EXS. 2018
- The Aspergillus nidulans pyruvate dehydrogenase kinases are essential to integrate carbon source metabolism. G3: Genes, Genomes, Genetics. 2018
- The influence of genetic stability on Aspergillus fumigatus virulence and azole resistance. G3: Genes, Genomes, Genetics. 2018
- Impact of Paracoccin Gene Silencing on Paracoccidioides brasiliensis Virulence. Mbio. 2017
- Drivers of genetic diversity in secondary metabolic gene clusters within a fungal species. PLoS Biology. 2017
- Evaluation of bronchoalveolar lavage fluid cytokines as biomarkers for invasive pulmonary aspergillosis in at-risk patients. Antibiotics. 2017
- Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology. ACS Biomaterials Science and Engineering. 2017
- The Cell Biology of the Trichosporon-Host Interaction. Frontiers in Cellular and Infection Microbiology. 2017
- Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity. Cell Metabolism. 2016
- Immunometabolic Pathways in BCG-Induced Trained Immunity. Cell Reports. 2016
- A Prediction Rule to Stratify Mortality Risk of Patients with Pulmonary Tuberculosis. Antibiotics. 2016
- Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer. PLoS Neglected Tropical Diseases. 2016
- The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells. Journal of Experimental Medicine. 2016
- Unveiling the effect of three-dimensional bioactive fibre mesh scaffolds functionalized with silanol groups on bacteria growth. Journal of Biomedical Materials Research. 2016
- IL-17A Promotes Intracellular Growth of Mycobacterium by Inhibiting Apoptosis of Infected Macrophages. Frontiers in Immunology. 2015
- Clinical Epidemiology of Buruli Ulcer from Benin (2005-2013): Effect of Time-Delay to Diagnosis on Clinical Forms and Severe Phenotypes. PLoS Neglected Tropical Diseases. 2015
- A Gß protein and the TupA co-regulator bind to protein kinase A Tpk2 to act as antagonistic molecular switches of fungal morphological changes. Antibiotics. 2015
- BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4<sup>+</sup>IL-17<sup>+</sup>TNF<sup>+</sup>IL-2<sup>+</sup> T cells. Vaccine. 2015
- Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis. Antibiotics. 2015
- Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages. European Journal of Immunology. 2014
- Functional characterization of a xylose transporter in Aspergillus nidulans. Biotechnology for Biofuels. 2014
- Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation. New England Journal of Medicine. 2014
- The Aspergillus nidulans signalling mucin MsbA regulates starvation responses, adhesion and affects cellulase secretion in response to environmental cues. Molecular Microbiology. 2014
- The genome sequence of the highly acetic acid-tolerant zygosaccharomyces bailii-derived interspecies hybrid strain ISA1307, isolated from a sparkling wine plant. DNA Research. 2014
- Involvement of Yeast HSP90 Isoforms in Response to Stress and Cell Death Induced by Acetic Acid. Antibiotics. 2013
- Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response. Antibiotics. 2013
- Evidence for Diversifying Selection in a Set of Mycobacterium tuberculosis Genes in Response to Antibiotic- and Nonantibiotic-Related Pressure. Molecular Biology and Evolution. 2013
- Identification of Metabolic Pathways Influenced by the G-Protein Coupled Receptors GprB and GprD in Aspergillus nidulans. Antibiotics. 2013
- Identification of glucose transporters in aspergillus nidulans. Antibiotics. 2013
- P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation. Antibiotics. 2013
- TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival. PLoS Neglected Tropical Diseases. 2013
- Functionality of the Paracoccidioides Mating a-Pheromone-Receptor System. Antibiotics. 2012
- Morphological heterogeneity of Paracoccidioides brasiliensis: Relevance of the Rho-like GTPase PbCDC42. Blood. 2012
- The Fate of Acetic Acid during Glucose Co-Metabolism by the Spoilage Yeast Zygosaccharomyces bailii. Antibiotics. 2012
- The rs5743836 polymorphism in TLR9 confers a population-based increased risk of non-Hodgkin lymphoma. Genes and Immunity. 2012
- Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a specific substrate of yeast metacaspase. Biochimica Et Biophysica Acta-Molecular Cell Research. 2011
- The C Allele of rs5743836 Polymorphism in the Human TLR9 Promoter Links IL-6 and TLR9 Up-Regulation and Confers Increased B-Cell Proliferation. Antibiotics. 2011
- Yeast chronological lifespan and proteotoxic stress: Is autophagy good or bad?. Biochemical SocIETy Transactions. 2011
- Application of flow cytometry for the identification of Staphylococcus epidermidis by peptide nucleic acid fluorescence in situ hybridization (PNA FISH) in blood samples. Antonie van Leeuwenhoek. 2011
- Genetic susceptibility to aspergillosis in allogeneic stem-cell transplantation. Blood. 2011
- Genetically-Determined Hyperfunction of the S100B/RAGE Axis Is a Risk Factor for Aspergillosis in Stem Cell Transplant Recipients. Antibiotics. 2011
- Immunogenetic Profiling to Predict Risk of Invasive Fungal Diseases: Where Are We Now?. Immunological Investigations. 2011
- Molecular biology of the dimorphic fungi Paracoccidioides spp. Fungal Biology Reviews. 2011
- Accumulation of Non-Superoxide Anion Reactive Oxygen Species Mediates Nitrogen-Limited Alcoholic Fermentation by Saccharomyces cerevisiae. Applied and Environmental Microbiology. 2010
- Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H 2 O 2 and superoxide dismutase activity. Proceedings of the National Academy of Sciences of the United States of America. 2010
- Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity. Blood. 2010
- The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans. Molecular Microbiology. 2010
- Cdc42p controls yeast-cell shape and virulence of Paracoccidioides brasiliensis. Fungal Genetics and Biology. 2009
- Neurodevelopmental delay in the Cln3¿ex7/8 mouse model for Batten disease. Genes, Brain and Behavior. 2009
- Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation. Experimental Hematology. 2009
- Yeast protein expression profile during acetic acid-induced apoptosis indicates causal involvement of the TOR pathway. Proteomics. 2009
- Drug-induced apoptosis in yeast. Biochimica Et Biophysica Acta-Molecular Cell Research. 2008
- T-1237C polymorphism of TLR9 gene is not associated with multiple sclerosis in the Portuguese population. Multiple Sclerosis. 2008
- NO-mediated apoptosis in yeast. Journal of Cell Science. 2007
- Nitric Oxide Signaling Is Disrupted in the Yeast Model for Batten Disease. Endocrinology. 2007
- An atypical active cell death process underlies the fungicidal activity of ciclopirox olamine against the yeast Saccharomyces cerevisiae. FEMS Yeast Research. 2007
- Low auxotrophy-complementing amino acid concentrations reduce yeast chronological life span. Mechanisms of Ageing and Development. 2007
- Genome size and ploidy of Paracoccidioides brasiliensis reveals a haploid DNA content: Flow cytometry and GP43 sequence analysis. Fungal Genetics and Biology. 2007
- Multiplex PCR identification of eight clinically relevant Candida species. Blood. 2007
- Responses of antioxidant defenses to Cu and Zn stress in two aquatic fungi. Heredity. 2007
- Study of disease-relevant polymorphisms in the TLR4 and TLR9 genes: A novel method applied to the analysis of the Portuguese population. Molecular and Cellular Probes. 2007
- Towards a molecular genetic system for the pathogenic fungus Paracoccidioides brasiliensis. Fungal Genetics and Biology. 2007
- A twenty-year survey of dermatophytoses in Braga, Portugal. International Journal of Dermatology. 2006
- New insights into the cell cycle profile of Paracoccidioides brasiliensis. Fungal Genetics and Biology. 2006
- An AIF orthologue regulates apoptosis in yeast. Journal of Cell Biology. 2004
- Isolation of an acetyl-CoA synthetase gene (ZbACS2) from Zygosaccharomyces bailii. Yeast. 2004
- The Spoilage Yeast Zygosaccharomyces bailii Forms Mitotic Spores: a Screening Method for Haploidization. Applied and Environmental Microbiology. 2003
- Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Endocrinology. 2002
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capítulo de livro
- The role of nitric oxide signalling in yeast stress response and cell death. 2017
- Gene Knockdown in Paracoccidioides brasiliensis Using Antisense RNA. Methods in Molecular Biology. 2012
- Stress and Cell Death in Yeast Induced by Acetic Acid 2012
- Sugar Metabolism in Yeasts: an Overview of Aerobic and Anaerobic Glucose Catabolism 2006
- Gene Disruption in the Yeast Kluyveromyces lactis 2003
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documento
- The glucocorticoid receptor as a biomarker and neuronal therapeutic target of a disease-improving bile acid in SCA3/MJD 2023
- Itaconate deficiency enhances anti-fungal effector functions of macrophages and confers resistance to infection with Aspergillus fumigatus 2023
- Evolutionary origin, population diversity, and diagnostics for a cryptic hybrid pathogen 2023
- PTX3 regulates macrophage effector function by modulating the intracellular carbon flux in response to A. fumigatus 2023
- Glutamine metabolism regulates the immune response to the fungal pathogen Aspergillus fumigatus 2019
- Paracoccin overexpression in Paracoccidioides brasiliensis reveals the influence of chitin hydrolysis on fungal virulence and host immune response 2019
- Genetically-determined NLRP3 hyperactivation confers risk to fungal disease by compromising macrophage function 2018
- Pentraxin-3 promotes IL-10-dependent immune protection to the oppurtunistic fungus Trichosporon asahii 2018
- Evaluation of alveolar cytokines as biomarkers for invasive pulmonary aspergillosis in high-risk patients 2018
- Ploidy and genetic transformation of Sporothrix brasiliensis 2018
- Towards a genetic toolkit for Sporothrix brasiliensis analysis 2018
- Tuberculosis severity and its association with pathogen phylogeny and properties 2017
- Sporothrix brasiliensis: ploidy and genetic transformation 2017
- Mycobacterium tuberculosis strains are differentially recognized by TLRs with an impact on innate immune responses and the outcome of infection: P1313 2012
- Studying the role of nitric oxide in the pathological mechanism of Batten disease 2008
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teses
- Regulação do metabolismo do ácido acético em Zygosaccharomyces bailii: estudos fisiológicos e moleculares 2001
- Estudos sobre a regulação do metabolismo intracelular de ácido acético na levedura Zygosaccharomyces bailii ISA 1307 1996
- Otimização de estratégias experimentais com vista à obtenção de mutantes da levedura Saccharomyces cerevisiae desreprimidos para o consumo de ácido acético e outros ácidos monocarboxílicos na presença de glucose 1995