publicações selecionadas
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artigo académico
- Localized cancer photodynamic therapy approach based on core–shell electrospun nanofibers. Materials Advances. 2024
- Nanochitin-coated electrospun membranes as platforms for localized cancer photodynamic therapy. ACS Applied Materials and Interfaces. 2024
- Evaluation of plant extracts as an efficient source of additives for active food packaging. Food Frontiers. 2022
- Application of PEG400 in the one-pot synthesis of 7-[4-alkyl- or (hetero)aryl-1H-1,2,3-triazol-1-yl]thieno[3,2-b]pyridines via SNAr and Cu(I)-Catalyzed Azide-Alkyne Cycloaddition and preliminary evaluation of their anti-tumour activity. Tetrahedron Letters. 2020
- Chemical characterization, antioxidant, anti-inflammatory and cytotoxic properties of bee venom collected in Northeast Portugal. Food and Chemical Toxicology. 2016
- Characterization of a Squaraine/Chitosan System for Photodynamic Therapy of Cancer. ACS Applied Polymer Materials. 2016
- Wild Roman chamomile extracts and phenolic compounds: enzymatic assays and molecular modelling studies with VEGFR-2 tyrosine kinase. Food Bioscience. 2016
- Extensional flow-based microfluidic device: Deformability assessment of red blood cells in contact with tumor cells. Biochip Journal. 2014
- Cytotoxicity of Coprinopsis atramentaria extract, organic acids and their synthesized methylated and glucuronate derivatives. Food Research International. 2014
- New insights into the effects of formulation type and compositional mixtures on the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plants. Food Bioscience. 2014
- Bioactivity of Different Enriched Phenolic Extracts of Wild Fruits from Northeastern Portugal: A Comparative Study. Plant Foods for Human Nutrition. 2013
- Synthesis of aminodiarylamines in the thieno[3,2-b]piridine series and effects on tumour cell growth inhibition, cell cycle and apoptosis. Revista Portuguesa de Farmácia. 2011
- Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle. European Journal of Medicinal Chemistry. 2010
- Novel 6-[(hetero)arylamino]thieno[3,2-b]pyridines: Synthesis and antitumoral activities. European Journal of Medicinal Chemistry. 2010
- Synthesis of new thieno[3,2-b]pyridine derivatives by palladium-catalyzed couplings and intramolecular cyclizations. Tetrahedron Letters. 2010
- Synthesis of novel 3-(aryl)benzothieno[2,3-c]pyran-1-ones from Sonogashira products and intramolecular cyclization: Antitumoral activity evaluation. European Journal of Medicinal Chemistry. 2009
- Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene through the redox profile. Electrochimica Acta. 2009
- New strategies for the synthesis of heteroannulated 2-pyridinones, substituted 2-quinolinones and coumarins from dehydroamino acid derivatives. Tetrahedron. 2008
- Reactivity of several deactivated 3-aminobenzo[b]thiophenes in the Buchwald-Hartwig C-N coupling. Scope and limitations. Tetrahedron. 2007
- Synthesis and antioxidant activity evaluation of new 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes obtained by Buchwald-Hartwig C-N cross-coupling. Bioorganic & Medicinal Chemistry. 2007
- Synthesis and antimicrobial activity studies of ortho-chlorodiarylamines and heteroaromatic tetracyclic systems in the benzo[b]thiophene series. Bioorganic & Medicinal Chemistry. 2006
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artigo de conferência
- Multifunctional graphene-based magnetic nanocarriers optimized with copolymer Pluronic F127 for biomedical applications 2017
- Magneto-sensitive liposomes containing manganese ferrite nanoparticles as nanocarriers for new promising antitumor thienopyridin-amine derivatives 2016
- Magnetoliposomes based on manganese ferrite nanoparticles for guided transport of antitumor drugs 2015
- New Di(hetero)arylethers and Di(hetero)arylamines in the Thieno [3,2-b]pyridine Series: Synthesis, Growth Inhibitory Activity on Human Tumor Cell Lines and Nanotumor Cells, Effects on Cell Cycle And on Apoptosis 2014
- Synthesis, molecular docking and biological Evaluation of New 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenyl]ureas as Potent Type II CEGFR-2 Tyrosine Kinase Inhibitors 2014
- Measurement of Red Blood Cells Deformation Índex in a Hyperbolic Microchannel 2013
- Interaction of benzothienoquinolines with DNA and lipid membranes monitored by fluorescence 2011
- Encapsulation of a new antitumoral fluorescent 6-(benzo[d]thiazo-2-ylamino)thieno[3,2-b]pyridine derivative in nanoliposomes 2010
- Fluorescence studies of benzothienoquinolines in lipid membranes 2010
- New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives : interaction with DNA and encapsulation in nanoliposomes 2010
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artigo de revista
- Phytochemical Composition and Bioactive Potential of Melissa officinalis L., Salvia officinalis L. and Mentha spicata L. Extracts. Antibiotics. 2023
- Magnetoliposomes Based on Magnetic/Plasmonic Nanoparticles Loaded with Tricyclic Lactones for Combined Cancer Therapy. Pharmaceutics. 2021
- Synthesis of Novel Methyl 7-[(Hetero)arylamino]thieno[2,3-b]pyrazine-6-carboxylates and Antitumor Activity Evaluation: Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Toxicity in Non-Tumor Cells. Biomolecules. 2021
- Chitosan/nanocellulose electrospun fibers with enhanced antibacterial and antifungal activity for wound dressing applications. Reactive and Functional Polymers. 2021
- Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy. Pharmaceutics. 2019
- Cotton-hydrogel composite for improved wound healing: antimicrobial activity and anti-inflammatory evaluation - part 2. Polymers for Advanced Technologies. 2019
- A Tailor-Made Protocol to Synthesize Yolk-Shell Graphene-Based Magnetic Nanoparticles for Nanomedicine. C. 2018
- Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia and dual stimuli-responsive drug delivery. Journal of Nanoparticle Research. 2018
- Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies. Nanoscale. 2017
- Magnetoliposomes as carriers for promising antitumor thieno[3,2-b]pyridin-7-arylamines: photophysical and biological studies. Nanoscale. 2017
- Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile. Food Research International. 2016
- A poly-e-caprolactone based biofilm carrier for nitrate removal from water. Amino Acids. 2016
- A poly-e-caprolactone based biofilm carrier for nitrate removal from water. Amino Acids. 2016
- Bioactive Properties of Tabebuia impetiginosa-Based Phytopreparations and Phytoformulations: A Comparison between Extracts and Dietary Supplements. Biomolecules. 2015
- The powerful in vitro bioactivity of Euterpe oleracea Mart. seeds and related phenolic compounds. Dyes and Pigments. 2015
- The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives. Food Research International. 2015
- Chemical characterisation and bioactive properties of Prunus avium L.: The widely studied fruits and the unexplored stems. Food Chemistry. 2015
- Is honey able to potentiate the antioxidant and cytotoxic properties of medicinal plants consumed as infusions for hepatoprotective effects?. Food Bioscience. 2015
- A new antitumoral Heteroarylaminothieno[3,2-b]pyridine derivative : its incorporation into liposomes and interaction with proteins monitored by fluorescence. Photochemical & Photobiological Sciences. 2014
- Effects of gamma radiation on chemical and antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of borututu. Innovative Food Science & Emerging Technologies. 2014
- Infusions and decoctions of Castanea sativa flowers as effective antitumor and antimicrobial matrices. Dyes and Pigments. 2014
- Benzothienoquinolines : new one-pot synthesis and fluorescence studies of their interaction with DNA and polynucleotides. Journal of Photochemistry and Photobiology A-Chemistry. 2014
- Benzothienoquinolines : new one-pot synthesis and fluorescence studies of their interaction with DNA and polynucleotides. Journal of Photochemistry and Photobiology A-Chemistry. 2014
- Antioxidant activity of aminodiarylamines in the thieno[3,2-b]pyridine series: Radical scavenging activity, lipid peroxidation inhibition and redox profile. Journal of Enzyme Inhibition and Medicinal Chemistry. 2014
- Cytotoxicity of Portuguese Propolis: The Proximity of the In VitroDoses for Tumor and Normal Cell Lines. Biomed Research International. 2014
- New insights into the effects of formulation type and compositional mixtures on the antioxidant and cytotoxic activities of dietary supplements based-on hepatoprotective plants. Food Bioscience. 2014
- Synergisms in antioxidant and anti-hepatocellular carcinoma activities of artichoke, milk thistle and borututu syrups. Dyes and Pigments. 2014
- Two-Dimensional PCA Highlights the Differentiated Antitumor and Antimicrobial Activity of Methanolic and Aqueous Extracts ofLaurus nobilisL. from Different Origins. Biomed Research International. 2014
- Leaves and decoction of Juglans regia L.: Different performances regarding bioactive compounds and in vitro antioxidant and antitumor effects. Dyes and Pigments. 2013
- New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death. European Journal of Medicinal Chemistry. 2013
- Fluorescence studies on potential antitumor 6-(hetero)arylthieno[3,2-b] pyridine derivatives in solution and in nanoliposomes. Journal of Photochemistry and Photobiology A-Chemistry. 2013
- 1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modelling Studies. Biomed Research International. 2013
- Antimicrobial activity, growth inhibition of human tumour cell lines, and phytochemical characterization of the hydromethanolic extract obtained from Sapindus saponaria L. aerial parts. Biomed Research International. 2013
- Antioxidant properties, anti-hepatocellular carcinoma activity and hepatotoxicity of artichoke, milk thistle and borututu. Dyes and Pigments. 2013
- Bioactivity and chemical characterization in hydrophilic and lipophilic compounds of Chenopodium ambrosioides L. Journal of Functional Foods. 2013
- Infusion and decoction of wild German chamomile: Bioactivity and characterization of organic acids and phenolic compounds. Food Chemistry. 2013
- Nutrients, phytochemicals and bioactivity of wild Roman chamomile: A comparison between the herb and its preparations. Food Chemistry. 2013
- Suillus luteus methanolic extract inhibits cell growth and proliferation of a colon cancer cell line. Food Research International. 2013
- Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells. Biomolecules. 2012
- Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2-carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies. European Journal of Medicinal Chemistry. 2011
- Fluorescence Studies on New Potential Antitumoral Benzothienopyran-1-ones in Solution and in Liposomes. Journal of Fluorescence. 2011
- New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: Interaction with DNA and nanosized liposomes. Nanoscale Research Letters. 2011
- New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: Interaction with DNA and nanosized liposomes. Nanoscale Research Letters. 2011
- Synthesis and evaluation of tumor cell growth inhibition of methyl 3-amino-6-[(hetero)arylethynyl]thieno[3,2-b]pyridine-2-carboxylates. Structure–activity relationships, effects on the cell cycle and apoptosis. European Journal of Medicinal Chemistry. 2011
- Synthesis of ß-Benzo[b]thienyldehydrophenylalanine Derivatives by One-Pot Palladium-Catalyzed Borylation and Suzuki Coupling (BSC) and Metal-Assisted Intramolecular Cyclization - Studies of Fluorescence and Antimicrobial Activity. European Journal of Organic Chemistry. 2005
- Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure-activity evaluation study. Bioorganic & Medicinal Chemistry Letters. 2004
- Synthesis of pure stereoisomers of benzo[b]thienyl dehydrophenylalanines by Suzuki cross-coupling. Preliminary studies of antimicrobial activity. Tetrahedron. 2004
- Palladium-Catalysed Amination of Electron-Deficient or Relatively Electron-Rich Benzo[b]thienyl Bromides- Preliminary Studies of Antimicrobial Activity and SARs. European Journal of Organic Chemistry. 2004
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capítulo de livro
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documento
- Magnetic/plasmonic liposomes as nanocarriers for novel antitumor tricyclic lactones against non-small cell lung cancer 2020
- Multifunctional graphene-based magnetic nanocarriers optimized with copolymer Pluronic F127 for biomedical applications 2017
- Magneto-sensitive liposomes containing manganese ferrite nanoparticles as nanocarriers for new promising antitumor thienopyridin-amine derivatives 2016
- Magnetoliposomes based on manganese ferrite nanoparticles for guided transport of antitumor drugs 2015
- New di(hetero)arylthioethers 1,3-diarylureas in the thieno[3,2-b]pyridine series as VEGFR2 tyrosine kinase Inhibitors: docking, synthesis, enzymatic and cellular assays 2013
- Synthesis of new n-[3-(thieno[3,2-b]pyridine-7-ylthio)phenyl]benzamides as potential inhibitors of VEGFR2 using rational design 2013
- Synthesis, docking, enzymatic and cellular assays of thieno[3,2-b]pyridine-thioether-1,3-diarylureas as VEGFR2 inhibitors 2013
- Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series 2013
- Thieno[3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines 2013
- Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine kinase inhibitors: synthesis, docking studies, enzymatic and cellular assays 2013
- 1-Aryl-3-[4-(thieno[3,2-b]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking, enzumatic and celular assays 2012
- Synthesis, growth inhibitory activity on human tumor cell lines and evaluation of the hepatotoxicity of di(hétero)arylethers and di(hétero)arylamines in the thieno[3,2-b]pyridine series 2012
- 1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 inhibitors: synthesis, docking enzymatic and cellular assays 2012
- Synthesis of novel 1-ary-3-[2-, 3- or 4-(thieno[3,2-b]pyridin-7-ylyhio)phenyl]ureas and evaluation as VEGFR2 tyrosine kinase inhibitors 2012
- Thieno [3,2-b]pyridine arylethers: synthesis and growth inhibitory activity on human tumor cell lines 2012
- Synthesis of tetracyclic systems and (thio)ureas from aminodi(hetero)arylamines in the thieno[3,2-b]pyridine series 2012
- Heteroarylether 1,3-diarylureas in the thieno[3,2-d]pyrimidine series as VEGFR2 tyrosine Kinase inhibitors: Synthesis, docking studies, enzymatic and cellular assays 2012
- Fluorescence studies of potential antitumoral 6-heteroarylthieno[3,2-b]pyridines in solution and in nanoliposomes 2012
- 1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR2 tyrosine kinase inhibitors: synthesis, docking, studies, enzymatic and cellular assays 2012
- Synthesis of novel 1-Aryl-3-[2-,3- Or 4-(Thieno[3,2-b]Pyridin-7-Ylthio)Phenyl]Ureas and evaluation as VEGFR2 Tyrosine kinase inhibitors 2012
- Synthesis of 1,3-diaryl(thio)ureas in the thieno[3,2-b]pyridine series by palladium-catalyzed couplings and reactions with aryliso(thio)cyanates 2011
- Interaction of benzothienoquinolines with DNA and lipid membranes monitored by fluorescence 2011
- Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies 2011
- Fluorescence studies of benzothienoquinolines in lipid membranes 2010
- Encapsulation of a new antitumoral fluorescent 6-(benzo[d]thiazo-2-ylamino)thieno[3,2-b]pyridine derivative in nanoliposomes 2010
- New potential antitumoral fluorescent tetracyclic thieno[3,2-b]pyridine derivatives: interaction with DNA and encapsulation in nanoliposomes 2010
- Fluorescence studies on new potential antitumoral benzothienopyran-1-ones in solution and in lipid membranes 2009
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teses