publicações selecionadas
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artigo académico
- Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3. Mechanisms of Ageing and Development. 2025
- Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB-Dependent Mechanisms. International Journal of Molecular Sciences. 2025
- The Chromenopyridine Scaffold: A Privileged Platform in Drug Design. Biomolecules. 2024
- The chick chorioallantoic membrane assay as an in vivo model for colon tumor analysis with optical coherence tomography. Expert Systems with Applications. 2024
- Differential impact of diesel exhaust particles on glutamatergic and dopaminergic neurons in Caenorhabditis elegans: A neurodegenerative perspective. Environment International. 2024
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3. Journal of Clinical Investigation. 2024
- Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells. Biomaterials Advances. 2023
- Mitochondrial Dysfunction and Decreased Cytochrome c in Cell and Animal Models of Machado-Joseph Disease. Cells. 2023
- Sustainable fluorescent dye-faujasite zeolite systems as tools for cancer bioimaging. African Journal of Biotechnology. 2023
- Glucose Metabolism Reprogramming in Bladder Cancer: Hexokinase 2 (HK2) as Prognostic Biomarker and Target for Bladder Cancer Therapy. Cancers. 2023
- Imidazolylpyrrolone-Based Small Molecules as Anticancer Agents for Renal Cell Carcinoma. Chemmedchem. 2023
- Synthesis and Biological Evaluation of Novel Chromeno[2,3-d]Pyrimidinones as Agents for Triple Negative Breast Cancer Treatment. European Journal of Medicinal Chemistry (IF 7.08, Q1 Chemistry, Organic). 2023
- Selective Cytotoxicity of Portuguese Propolis Ethyl Acetate Fraction towards Renal Cancer Cells. Biomolecules. 2022
- Modifier pathways in polyglutamine (PolyQ) diseases: from genetic screens to drug targets (IF: 8.0). Cellular and Molecular Life Sciences. 2022
- Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicine. 2022
- Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders. Frontiers in Neurology. 2021
- A imagem estereotipada dos chineses em crónicas portuguesas. Diacrítica. 2021
- Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of Disease. 2021
- Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle. Free Radical Biology and Medicine. 2021
- Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases. Data in Brief. 2020
- In vivo efficacy studies of chromene-based compounds in triple-negative breast cancer: A systematic review. European Journal of Pharmacology. 2020
- Unravelling the anticancer potential of functionalized chromeno[2,3-b ] pyridines for breast cancer treatment. Bioorganic Chemistry. 2020
- A Convenient One-pot Synthesis of Chromenyl Acrylates and Acrylonitriles. Synlett. 2020
- Loss of egli-1, the Caenorhabditis elegans Orthologue of a Downstream Target of SMN, Leads to Abnormalities in Sensorimotor Integration. Molecular Neurobiology. 2020
- GST-4-Dependent Suppression of Neurodegeneration in C. elegans Models of Parkinson's and Machado-Joseph Disease by Rapeseed Pomace Extract Supplementation. Frontiers in Aging Neuroscience. 2019
- Adenine Derivatives: Promising Candidates for Breast Cancer Treatment. European Journal of Organic Chemistry. 2018
- Origin and spread of human mitochondrial DNA haplogroup U7 (IF: 5.228). Acta Cytologica. 2017
- Reconciling evidence from ancient and contemporary genomes: a major source for the European Neolithic within Mediterranean Europe (IF: 4.847). Proceedings of the Royal SocIETy B-Biological Sciences. 2017
- Biological Importance of Structurally Diversified Chromenes. European Journal of Medicinal Chemistry. 2016
- Fine Time Scaling of Purifying Selection on Human Nonsynonymous mtDNA Mutations Based on the Worldwide Population Tree and Mother-Child Pairs (IF: 5.089). Human Mutation. 2015
- Novel structurally similar chromene derivatives with opposing effects on p53 and apoptosis mechanisms in colorectal HCT116 cancer cells. European Journal of Pharmaceutical Sciences. 2015
- ChemInform Abstract: Tandem Cyclization of a Bispyridinium Chloride: Facile Synthesis of Substituted Indolizines.. ChemInform. 2014
- A substantial prehistoric European ancestry amongst Ashkenazi maternal lineages (IF: 10.742). Nature Communications. 2013
- Tandem Cyclization of a Bispyridinium Chloride: Facile Synthesis of Substituted Indolizines. Synlett. 2013
- Conceptions de formation dans des institutions portugaises de formation initiale d’enseignants d'éducation physique : des connaissances nécessaires aux conseils pédagogiques. Ejournal de la recherche sur l'intervention en éducation physique et sport -eJRIEPS. 2013
- Práticas de ensino em contexto de estágio: reflexões e experiências do estudante estagiário e do orientador da Faculdade. Revista Portuguesa de Ciências do Desporto. 2013
- Population expansion in the North African Late Pleistocene signalled by mitochondrial DNA haplogroup U6. BMC Evolutionary Biology. 2010
- The trans-Saharan slave trade - clues from interpolation analyses and high-resolution characterization of mitochondrial DNA lineages (IF: 3.702). BMC Evolutionary Biology. 2010
- Post-last glacial maximum expansion from Iberia to North Africa revealed by fine characterization of mtDNA H haplogroup in Tunisia (IF: 2.756). American Journal of Physical Anthropology. 2009
- Academic Procrastination: Associations with Personal, School, and Family Variables. The Spanish Journal of Psychology. 2009
- The Diversity Present in 5140 Human Mitochondrial Genomes (IF: 12.303). American Journal of Human Genetics. 2009
- Data from complete mtDNA sequencing of Tunisian centenarians: Testing haplogroup association and the “golden mean” to longevity (IF: 4.179). Mechanisms of Ageing and Development. 2009
- Microbial monitoring of a subsurface constructed wetland treating domestic wastewater 2009
- Migration of Chadic speaking pastoralists within Africa based on population structure of Chad Basin and phylogeography of mitochondrial L3f haplogroup (IF:4.294). BMC Evolutionary Biology. 2009
- The Condensation of Salicylaldehydes and Malononitrile Revisited: Synthesis of New Dimeric Chromene Derivatives. Journal of Organic Chemistry. 2008
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artigo de conferência
- Exosome-mediated MEK1 silencing is a promising approach against triple negative breast cancer regression 2022
- A formação inicial de professores de educação física em Portugal e sua relação com o processo de Bolonha 2014
- A organização e a gestão do ensino e da aprendizagem no contexto do estágio pedagógico supervisionado em instituições portuguesas de formação inicial de professores 2012
- Synthesis and Thermal Behavior of An Amorphous Solid Polymer Electrolyte. ECS Transactions. 2010
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capítulo de livro
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documento
- Acoustic stimulation based on piezoelectric materials enhanced anti-proliferative activity of triple-negative breast cancer cells (https://doi.org/10.34620/978-972-745-346-7 ) 2025
- Novel chromene-based compounds as a therapeutic strategy for triple negative breast cancer and muscle invasive bladder cancer 2024
- Synthesis of chromene[2,3-b]pyridines and characterization of their anticancer potential for the treatment of breast cancer 2023
- Síntese de cromeno[2,3-b]piridinas e caracterização do seu potencial anticancerígeno para o tratamento do cancro da mama 2023
- Hexokinase II (HKII) as prognostic biomarker and target for bladder cancer therapy 2022
- Exosome-mediated MEK1 silencing is a promising approach against triple negative breast cancer regression 2022
- Disfunção cognitiva em doentes com doença arterial periférica 2022
- Exossomas modificados para o desenvolvimento de novas terapias para cancro de mama triplo negativo 2021
- A new lead compound for triple negative breast cancer therapy 2021
- Hexokinase II (HKII) is a prognostic biomarker for bladder cancer patients: Antitumoral activity of the HKII inhibitor 2-deoxy-D-glucose 2021
- Upregulation of Hexokinase II (HKII) impacts survival of bladder cancer patients: Effects of HKII inhibition by 2-deoxy-D-glucose 2021
- Chromene derivatives: a new strategy to overcome renal cancer resistance. 2019
- Exploitation of novel chromene derivatives for breast cancer treatment. 2019
- Novas moléculas baseadas na unidade de cromeno como candidatas à terapia do carcinoma das células renais (CCR). 2019
- Síntese e atividade biológica de novos agentes anticancerígenos para o tratamento do cancro da mama. 2019
- Chromene-based compounds as candidates for renal cell cancer treatment. 2019
- In vitro and in vivo efficacy evaluation of drug delivery systems based on zeolites. 2019
- Biological activity of novel targeted inhibitors for renal cell cancer therapy. 2019
- In vitro and in vivo evaluation of new chromene derivatives as potent anticancer agents. 2019
- Synthesis of functionalized chromeno[2,3-b]pyridines: promising agents for breast cancer treatment. 2019
- Chromene-based molecules as targeted inhibitors for renal cell cancer therapy. 2019
- New chromene-based molecules as microtubule destabilizers and pro-apoptotic agents in cancer 2018
- Chemical and biological characterization of chalcones and 4H-chromenes: exploitation as anticancer agents. 2018
- Discovery of chromene-based molecules as apoptosis-inducers by G2/M cell-arrest. 2018
- Unraveling the anticancer molecular mechanisms of new chromene-based drugs. 2018
- Chromene-based drug candidates for cancer treatment. 2018
- New chromene-based drug candidates for cancer treatment 2017
- Chromene derivatives as anticancer agents: synthesis and biological evaluation. 2016
- Anticancer profile of a selection of new chromene-based compounds 2015
- Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB Dependent Mechanisms