publicações selecionadas
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artigo académico
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3 (IF: 19.47). The Journal of Clinical Investigation. 2024
- Drug repurposing of dopaminergic drugs to inhibit ataxin-3 aggregation. Biomedicine & Pharmacotherapy. 2023
- Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing. Neurobiology of Disease. 2022
- Pre-clinical study of a 5HT1A specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease. Journal of Neurochemistry. 2022
- Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of Disease. 2021
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artigo de conferência
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artigo de revista
- Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model. Biomedicines. 2023
- Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicines. 2022
- Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle. Free Radical Biology and Medicine. 2021
- Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases. Data in Brief. 2020
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documento
- Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of Neurodegenerative Diseases 2024
- Novel genetic modifiers of SCA3/MJD: an EMS screening in a C. elegans model of the disease 2024
- Serotonin as an endogenous regulator of proteostasis: towards mechanism. 2023
- Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Animal Organism Phenotypic Assay 2023
- Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Organism Phenotypic Assay. 2023
- Repurposing dopaminergic drugs to prevent Ataxin 3 aggregation 2023
- FastProtAct - FAST-throughput phenotypic assay to identify compounds with PROTeostasis ACTivity. 2023
- Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay 2023
- Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay. 2023
- Motor coordination and balance ameliorated after treatment of the CMVMJD135 mouse model of Spinocerebellar Ataxia Type 3 with befiradol 2022
- Neuroprotective effect of a Hemerocallis citrina extract in a C. elegans model of Machado-Joseph disease 2022
- Neuroprotective effect of a Hemerocallis citrina extract in a C. elegans model of Machado-Joseph disease. 2022
- Novel genetic modifiers of SCA3/MJD: an EMS screening in a C. elegans model of the disease 2022
- Chemical screening for novel therapeutic target identification in Machado-Joseph disease 2022
- Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease. 2022
- Pre and post-symptomatic treatment with NLX-112 improved the balance and motor coordination of the CMVMJD135 mouse model of Machado-Joseph Disease 2022
- Development of a high-throughput phenotypic assay to screen for chemical enhancers of proteostasis activity in Caenorhabditis elegans 2022
- Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease 2022
- NLX-112 improved the motor coordination and balance in a Mouse Experimental Model of Machado-Joseph Disease 2021
- Pterospartum tridentatum: phytochemical profile and antioxidant activity of methanolic extracts. 2021
- Neuroprotective and antioxidant effects of Maranta arundinacea and Porophyll umruderale extracts in Caenorhabditis elegans. 2021
- Targeting of the serotonin (1A) receptor suppresses mutant ataxin-3 pathogenesis in C. elegans. 2019
- Identification of novel genetic modifiers of machado-joseph disease (MJD/SCA3) using whole-exome sequencing. 2019
- Neuroprotective and antioxidant effects of Maranta arundinacea and Porophyllum ruderale in Caenorhabditis elegans. 2019
- Targeting of the Serotonin (1A) Receptor Suppresses Mutant Ataxin-3 Pathogenesis in C. elegans 2019
- whole-exome sequencing of discordant and concordant affected sib pairs in spinocerebellar ataxia 3 (SCA3): a tool to identify novel modifier genes and highlight disrupted molecular pathways. 2018
- Antioxidant and neuroprotective effects of Hyptis suaveolens, Hytis pectinata and Hyptis marrubioides in Caenorhabditis elegans 2018
- Antioxidant and neuroprotective effects of Hyptis suaveolens, Hyptis pectinata and Hyptis marrubioides in Caenorhabditis elegans. 2018
- The neuroprotective effect of Hyptis suaveolens, Hyptis pectinata and Hyptis marrubioides in Caenorhabditis elegans model of SCA3/MJD. 2018
- Antioxidant and neuroprotective effects of Hyptis suaveolens,Hyptis pectinata and Hyptis marrubioides in Caenorhabditiselegans. Chinese Medicine. 2018
- Neuroprotective effects of Hyptis plant extracts in C. elegans models of neurodegeneration 2017
- Prevalência e Determinantes do Risco de Queda em Idosos Institucionalizados 2016
- Raw data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases
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teses