publicações selecionadas
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artigo académico
- Valence-specific ensembles in the laterodorsal tegmentum encode salient stimuli and modulate motivated behavior 2026
- Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies. Advanced Science. 2025
- Differential effects of lifespan-extending genetic manipulations in an animal model of MJD/SCA3. Mechanisms of Ageing and Development. 2025
- Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB-Dependent Mechanisms. International Journal of Molecular Sciences. 2025
- Differential impact of diesel exhaust particles on glutamatergic and dopaminergic neurons in Caenorhabditis elegans: A neurodegenerative perspective. Environment International. 2024
- Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3. Journal of Clinical Investigation. 2024
- Drug repurposing of dopaminergic drugs to inhibit ataxin-3 aggregation. Biomedicine & Pharmacotherapy. 2023
- Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model. Biomedicine. 2023
- Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans. Biomedicine. 2022
- Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing. Neurobiology of Disease. 2022
- Pre-clinical study of a 5HT1A specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease. Journal of Neurochemistry. 2022
- Identification of the 5-HT1A serotonin receptor as a novel therapeutic target in a C. elegans model of Machado-Joseph disease. Neurobiology of Disease. 2021
- Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle. Free Radical Biology and Medicine. 2021
- Data on the effects of Hyptis spp. and Lycium spp. plant extracts in C. elegans models of genetically determined neurodegenerative diseases. Data in Brief. 2020
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artigo de conferência
- Befiradol treatment ameliorated the motor dysfunction of Spinocerebellar Ataxia Type 3 mouse model 2022
- Chemical screening for novel therapeutic target identification in Machado-Joseph disease 2022
- Pre- clinical study of a 5HT1A specific agonist in the CMVMJD135 mouse model of Machado– Joseph disease 2022
- The molecular tweezer CLR01 reduces motor impairments and neuropathology in spinocerebellar ataxia type 3 in vivo models 2022
- Evaluation of antioxidant properties of Apocynum venetum 2021
- Antioxidant and neuroprotective effects of Hyptis suaveolens, Hytis pectinata and Hyptis marrubioides in Caenorhabditis elegans 2018
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documento
- Neuronal Diversity in the Nucleus Accumbens: Single-Nucleus RNA Sequencing Reveals Distinct Transcriptional Signatures in Reward and Aversion 2025
- Re-activation of a cocaine-responsive ensemble but not a shock-responsive ensemble in the nucleus accumbens controls behavioral preference 2025
- Advancing Proteostasis-enhancing Therapies: A Novel Assay for Drug Discovery in Machado-Joseph disease 2025
- Novel genetic modifiers of SCA3/MJD: an EMS screening in a C. elegans model of the disease 2024
- ATXN3 is A Key Regulator of Neuronal Splicing and Tau Isoform Dynamics 2024
- Aripiprazole-related compounds reduce cellular abundance of toxic ATXN3 in models of MJD/SCA3 2024
- Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of spinocerebellar ataxias 2024
- Therapeutic efficacy of chronic 5-HT1A receptor agonism by NLX-112 (befiradol) in Spinocerebellar Ataxia Type 3 mice 2024
- Establishment of a Novel Assay to identify drugs that enhance protein homeostasis: towards treatment of Neurodegenerative Diseases 2024
- Novel genetic modifiers of MJD/SCA3: an EMS screening in a C. elegans model of the disease 2024
- Serotonin as an endogenous regulator of proteostasis: towards mechanism. 2023
- Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Animal Organism Phenotypic Assay 2023
- Unveiling Promising Compounds for Boosting Proteostasis: A Rapid Whole-Organism Phenotypic Assay. 2023
- Repurposing dopaminergic drugs to prevent Ataxin 3 aggregation 2023
- FastProtAct - FAST-throughput phenotypic assay to identify compounds with PROTeostasis ACTivity. 2023
- Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay 2023
- Identification of novel molecules with proteostasis enhancement activity using a whole-animal based fast-throughput phenotypic assay. 2023
- Motor coordination and balance ameliorated after treatment of the CMVMJD135 mouse model of Spinocerebellar Ataxia Type 3 with befiradol 2022
- Neuroprotective effect of a Hemerocallis citrina extract in a C. elegans model of Machado-Joseph disease 2022
- Neuroprotective effect of a Hemerocallis citrina extract in a C. elegans model of Machado-Joseph disease. 2022
- Novel genetic modifiers of SCA3/MJD: an EMS screening in a C. elegans model of the disease 2022
- Chemical screening for novel therapeutic target identification in Machado-Joseph disease 2022
- Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease. 2022
- The molecular tweezer CLR01 reduces motor impairments and neuropathology in spinocerebellar ataxia type 3 in vivo models 2022
- Pre and post-symptomatic treatment with NLX-112 improved the balance and motor coordination of the CMVMJD135 mouse model of Machado-Joseph Disease 2022
- Development of a high-throughput phenotypic assay to screen for chemical enhancers of proteostasis activity in Caenorhabditis elegans 2022
- Preclinical study of a 5-HT1A receptor specific agonist in the CMVMJD135 mouse model of Machado-Joseph disease 2022
- Aripiprazole offsets mutant ATXN3-induced motor dysfunction by targeting dopamine D2 and serotonin 1A and 2A receptors in C. elegans. 2021
- NLX-112 improved the motor coordination and balance in a Mouse Experimental Model of Machado-Joseph Disease 2021
- Suppression of proteotoxic stress by serotonergic signaling 2021
- Pterospartum tridentatum: phytochemical profile and antioxidant activity of methanolic extracts. 2021
- Neuroprotective and antioxidant effects of Maranta arundinacea and Porophyll umruderale extracts in Caenorhabditis elegans. 2021
- Development of a high-throughput phenotypic assay to screen for chemical enhancers of proteostasis activity in Caenorhabditis elegans 2021
- The molecular tweezer CLR01 delay disease onset and reduce neurotoxicity in animal models of Machado-Joseph disease 2020
- Targeting of the serotonin (1A) receptor suppresses mutant ataxin-3 pathogenesis in C. elegans. 2019
- Identification of novel genetic modifiers of machado-joseph disease (MJD/SCA3) using whole-exome sequencing. 2019
- Chemogenomics screening for novel therapeutic target identification in a C. elegans model of Machado-Joseph disease 2019
- Neuroprotective and antioxidant effects of Maranta arundinacea and Porophyllum ruderale in Caenorhabditis elegans. 2019
- Targeting of the Serotonin (1A) Receptor Suppresses Mutant Ataxin-3 Pathogenesis in C. elegans 2019
- whole-exome sequencing of discordant and concordant affected sib pairs in spinocerebellar ataxia 3 (SCA3): a tool to identify novel modifier genes and highlight disrupted molecular pathways. 2018
- Antioxidant and neuroprotective effects of Hyptis suaveolens, Hyptis pectinata and Hyptis marrubioides in Caenorhabditis elegans. 2018
- The neuroprotective effect of Hyptis suaveolens, Hyptis pectinata and Hyptis marrubioides in Caenorhabditis elegans model of SCA3/MJD. 2018
- Neuroprotective effects of Hyptis plant extracts in C. elegans models of neurodegeneration 2017
- Adaptive changes of cholinergic projections to the nucleus accumbens bidirectionally mediate cocaine reinforcing effects
- Dissociable neuronal substrates for positive and negative valence stimuli in the nucleus accumbens
- Efficacy of chronic 5-HT 1A receptor agonism by NLX-112 in a mouse model of Spinocerebellar Ataxia type 3
- PRO-FitS: a novel phenotypic assay to identify enhancers of proteostasis in C. elegans
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teses